What is the Difference Between PRP and PRF?

PRP works best on people with hyperpigmentation, acne scars, fine lines, and wrinkles. Within a month, you ought to notice a change in the texture of your skin and fewer scarring and dark patches. When treating deep wrinkles or hollows, PRP is less effective.

Many people wish to regain the youthful radiance of their skin, and PRP and PRF are two of the best options. Platelet-rich plasma, also known as PRP, has been used for many years to treat orthopedic injuries, improve hair growth, and rejuvenate the skin. A second similar treatment is available today called PRF (or platelet-rich fibrin).

Though the treatment names sound almost the same and are utilized similarly, PRF varies from PRP in some significant aspects. In this article, we will know the difference between PRP and PRF and how it works.

PRP and PRF Treatments

PRP and PRF have medical and cosmetic uses and are incredibly trendy treatments for various conditions. They have grown in prominence over the past few years as new medical discoveries continue improving their usefulness in cosmetics and medicine.

PRP and PRF are made from a small sample of your blood drawn at the beginning of your treatment. Platelets, fibrin, plasma (the liquid component of blood), red and white blood cells and other elements of your blood are separated using specialized processing methods.

Platelets and Plasma

The liquid component of whole blood is called plasma. It is mainly made of water and proteins and serves as a medium for the movement of platelets, white blood cells, and red blood cells throughout the body.

Blood cells called platelets, also known as thrombocytes, are responsible for blood clotting and other vital development and healing processes.

Platelet activation is a crucial component of the body’s natural healing processes.


It is a commonly known fact that the body can heal itself. However, the specifics of the body’s natural healing capabilities have only been recently discovered. A type of regenerative substance known as platelet-rich plasma treatment can take advantage of these healing properties and boost the natural growth factors your body produces while healing tissue.

Injections of platelet-rich plasma (PRP) are becoming more and more popular for treating a wide range of ailments, including hair loss and sports injuries. A patient’s blood cells are used in the procedure to hasten the healing of a specific area. It can treat musculoskeletal conditions by utilizing each patient’s integral healing mechanism.

One to several tubes of your blood is used to prepare PRP injections, which is done by putting the vial in a centrifuge to obtain a concentration of platelets.

The damaged or less-than-perfect body tissue is subsequently given an injection of these activated platelets. The injection of PRP causes the release of growth factors, which promote and boost your body’s production of reparative cells.

One of the main benefits of PRP injections is that they can lessen the need for more extreme medicines like opioids or anti-inflammatories.

PRP injections also have very few side effects. They are safe because your body won’t reject or react badly to them as they are derived from your blood.


Platelet-rich fibrin (PRF) is a fibrin matrix that can operate as a resorbable membrane used to retain platelet cytokines, growth factors, and cells before they are potentially released.

Platelet Rich Fibrin (PRF), the active form of fibrin, is a form of fibrinogen present in blood plasma.

In 2001, PRF Membrane Research and Development was pioneered in France by Dr. Joseph Choukroun, MD. Its production technique aims to collect released cytokines and platelets in a fibrin clot.

Although platelets and leukocyte cytokines play a significant role in the function of this biomaterial, the fibrin matrix that supports them is essential in forming the defining factors that determine the true therapeutic potential of PRF.

PRF represents a new innovative step in the medicinal use of platelet gel. Unlike other platelet concentrates, this method only needs centrifugation of the original blood without any additives or gelling agents.

PRF injections are effective if you want to have vibrant facial skin. The skin surrounding the eyes is naturally rejuvenated by platelet-rich fibrin or PRF. The treatment tightens and strengthens the skin by producing more collagen, reducing the appearance of fine wrinkles, sagging, and discoloration. 

Here are PRF’s advantages over PRP:

  • PRF has an immune system-boosting impact
  • Blood is not biochemically handled – Anticoagulants and bovine thrombin are not necessary
  • Favorable healing as a result of the gradual polymerization
  • Cost-efficient and simple procedure
  • The PRF promotes hemostasis, increased cell migration, and proliferation efficiency

The Difference Between PRP and PRF Treatments

The main distinction between these procedures is how your blood is drawn before the procedure. PRP involves thoroughly separating the plasma layer from your blood by spinning it quickly in a centrifuge.

Your blood is spun less quickly during PRF, allowing specific white blood cells, stem cells, and fibrin to stay in the platelet layer.

Because fewer cells are injured due to the slow spin, more healing platelets are present in PRF. Compared to PRP, PRF has a platelet concentration that is roughly 2–5 times higher.

The usage of anticoagulants is another obvious distinction. Anticoagulants, which stop the blood from clotting during injection, are added to a vial of PRP treatment. Anticoagulants are not added when using PRF.

As a result, a porous fibrin matrix can be produced, signaling the platelets to release their growth factors gradually. PRF releases growth factors for up to a week, while PRP only does so for a few hours. It is proven that the effects of the delayed release in PRF are more potent and last longer.

PRP works best on people with hyperpigmentation, acne scars, fine lines, and wrinkles. Within a month, you ought to notice a change in the texture of your skin and fewer scarring and dark patches. When treating deep wrinkles or hollows, PRP is less effective.

The same problems can be treated with PRP and PRF, although PRF is preferable if you have deeper wrinkles, hollows, or more pronounced indications of aging. You can have enhanced effects by mixing PRF with additional treatments like dermal fillers.

Contact GloDerma for More Details About PRP and PRF

To know more about PRP and PRF and what is best for you, GloDerma will happily consult you on the best course of action for your aesthetic goals. You can visit them at 204 Floral Vale Blvd, Yardley, PA 19067, or call (267) 399-3456 or contact them by email at [email protected].

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